We are in the process of changing our lab from running on dewars of liquid N2 to a nitrogen generator (running LC-orbitrap and triple quad). Has anyone else gone through this process? Did it have an impact on any of your NTA results? Is the purity you get from your N2 generator sufficient, or do you need to supplement with tanks of ultra-high purity?
We have a nitrogen generator feeding our LC-orbitrap and do not supplement with anything else. It went down recently, and I temporarily had to switch to a dewar and saw no difference in data quality. For reference, our generator produces 99-99.99% purity.